Vascular Endothelial Growth Factor in Systemic Capillary Leak Syndrome

Systemic capillary leak syndrome is a rare disorder characterized by acute attacks of severe vascular hyperpermeability causing hypotension and shock. All patients have a paraproteinemia. There is a rarer variant of this syndrome in which the same symptoms appear in a chronic form. The diagnosis is made by exclusion of other causes. The cause has not been elucidated, and no treatment has been shown effective.


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-- Willem Joost Lesterhuis, MD, Alexander J. Rennings, MD, William P. Leenders, PhD, Arjan Nooteboom, PhD, Cornelis J. Punt, MD, PhD, Fred C. Sweep, PhD, Peter Pickkers, MD, Anneke Geurts-Moespot, MS, Hanneke W. Van Laarhoven, MD, PhD, Johan Van der Vlag, PhD, Jo H. Berden, MD, PhD, Cor T. Postma, MD, Phd, Jos W. Van der Meer, MD, PhD

This article was originally published in the June 2009 issue of The American Journal of Medicine.