When I was a medical student, atherosclerosis was seen as a process resembling the deposition of calcium deposits in pipes in an old house with gradual accumulation of precipitated minerals on the inner walls of these pipes. Basic science and clinical research over the last 40 years have made it clear that the process that actually leads to atherosclerosis involves inflammatory changes within the arterial wall that begin after some form of injury to the vascular endothelium that lines the arteries.
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-- Joseph S. Alpert, MD
This article was originally published in the May 2009 issue of The American Journal of Medicine.
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